Title: Neuromuscular blockade control based on self-oscillating adaptive systems
Authors: Bertinho Costa , João Lemos xvii
Abstract: The neuromuscular blockade control is a task that is performed manually during a general human anesthesia. The anesthetist uses his/her experience and the drug prescribing information to define a bolus sequence to be administrated or to adjust a continuous infusion rate. However due to the large variability among patients, there is a risk of overdoses and under-doses, the neuromuscular blockade level is usually too deep, or it can have an oscillatory behavior, causing a longer recovering period. The characterization of the pharmacokinetics and pharmacodynamics for a particular drug/patient is the biggest practical challenge. This paper explores the drug prescribing information, the clinical practice information and the concept self-oscillating adaptive systems to support the design of an automated neuromuscular blockade controller. To address the several phases of the neuromuscular blockade process and model uncertainty, a controller based on a state machine is proposed that complies with the clinical requirements.
Publication date: 2012-07-16
Online entry date: 2013-05-08
Conference: CONTROLO’2012
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